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Anti-Galectin 9 antibody

SKU Product Brand Unit Availability Price Quantity  
AB-06-1832
Anti-Galectin 9 antibody
Erpan Tech In stock

Specifications        

Product Cat#: AB-06-1832
Product type: Primary antibody
Antigen: Galectin 9
Immunogen: KLH conjugated synthetic peptide derived from mouse Galectin 51-150/353
Species immunized: Rabbit
Isotype: IgG
Applications: Western Blot (1:500-1:2000)
Reactivity: Human, Mouse, Rat, Pig, Cow
Clonality (clone number): Polyclonal
Form: Liquid
Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Concentration: 1 mg/ml
Purity: Protein A affinity purified
Storage: Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Alternative names: Ecalectin
galectin9
HOM HD 21
HOMHD21
HUAT
Lectin galactoside binding soluble 9
LGAL S9
LGALS 9
LGALS9
LGALS9A
MGC117375
MGC125973
MGC125974
Urate transporter/channel protein
Galectin-9
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Target information

Binds galactosides (PubMed:18005988). Has high affinity for the Forssman pentasaccharide (PubMed:18005988). Ligand for HAVCR2/TIM3 (PubMed:16286920). Binding to HAVCR2 induces T-helper type 1 lymphocyte (Th1) death (PubMed:16286920). Also stimulates bactericidal activity in infected macrophages by causing macrophage activation and IL1B secretion which restricts intracellular bacterial growth (By similarity). Ligand for P4HB; the interaction retains P4HB at the cell surface of Th2 T-helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307). Ligand for CD44; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (By similarity). Promotes ability of mesenchymal stromal cells to suppress T-cell proliferation (PubMed:23817958). Expands regulatory T-cells and induces cytotoxic T-cell apoptosis following virus infection (PubMed:20209097). Activates ERK1/2 phosphorylation inducing cytokine (IL-6, IL-8, IL-12) and chemokine (CCL2) production in mast and dendritic cells (PubMed:24465902, PubMed:16116184). Inhibits degranulation and induces apoptosis of mast cells (PubMed:24465902). Induces maturation and migration of dendritic cells (PubMed:25754930, PubMed:16116184). Inhibits natural killer (NK) cell function (PubMed:23408620). Can transform NK cell phenotype from peripheral to decidual during pregnancy (PubMed:25578313). Astrocyte derived galectin-9 enhances microglial TNF production (By similarity). May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. May provide the molecular basis for urate flux across cell membranes, allowing urate that is formed during purine metabolism to efflux from cells and serving as an electrogenic transporter that plays an important role in renal and gastrointestinal urate excretion (By similarity). Highly selective to the anion urate (By similarity).

Provider

Erpantech Laboratory

download

MSDS-AB-06-1832.pdf (135 downloads)