Anti-PAK3 (Ab-154) antibody
Specifications
| Product Cat#: | AB-07-3432 |
| Product type: | Primary antibody |
| Antigen: | PAK3 |
| Immunogen: | A synthetic peptide derived from human PAK3 around the phosphorylation site of serine 154 (Y-M-SP-F-T). The exact amino-acid sequence is proprietary. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | ELISA (1:40000); Western Blot (1:200-1:2500) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | PBS (without Mg2+ and Ca2+ ), pH 7.4, 0.02% sodium azide and 50% glycerol |
| Concentration: | 1 mg/ml |
| Purity: | Antigen affinity chromatography |
| Storage: | Aliquot and freeze at -20°C. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Beta-PAK; CDC42/RAC effector kinase PAK-B; EC 2.7.1.; EC 2.7.11.1; Kinase PAK3; Oligophrenin-3; OPHN3; P21-activated kinase 3; P65-PAK; PAK-3; PAKB; Serine/threonine-protein kinase PAK 3; STK4 |
Target information
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development.
Provider
Erpantech Laboratory
