Anti-CAMK4 antibody
Specifications
| Product type: | Primary antibody |
| Antigen: | CAMK4 |
| Immunogen: | Purified recombinant fragment of human CAMK4 expressed in E. Coli. |
| Species immunized: | Mouse |
| Isotype: | IgG1 |
| Applications: | Western Blot (1:400-1:2000); Immunohistochemistry (1:100-1:200); Immunocytochemistry (1:100-1:200); Flow Cytometry (1:50-1:200) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal, B8-C5 |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 0.05% NaN3 and 40% Glycerol. |
| Concentration: | 1mg/ml |
| Purity: | Protein A/G affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Brain Ca(2+) calmodulin dependent protein kinase type 4 antibody |
| Brain Ca(2+) calmodulin dependent protein kinase type IV antibody | |
| Brain Ca++-calmodulin dependent protein kinase type IV antibody | |
| Calcium/calmodulin dependent protein kinase type 4 catalytic chain antibody | |
| Calcium/calmodulin dependent protein kinase type IV catalytic chain antibody | |
| Calcium/calmodulin dependent protein kinase IV antibody | |
| Calcium/calmodulin dependent protein kinase type IV antibody | |
| Calcium/calmodulin-dependent protein kinase type IV antibody | |
| CAM kinase 4 antibody | |
| CAM kinase GR antibody | |
| CAM kinase IV antibody | |
| CAM kinase-GR antibody | |
| CaMK 4 antibody | |
| CAMK GR antibody | |
| CaMK IV antibody | |
| Camk4 antibody | |
| CaMKGR antibody | |
| IV antibody |
Target information
Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4+/CD8+ double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on ‘Ser-133’ in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18.
Provider
Erpantech Laboratory
