Anti-DFNA5 antibody
Specifications
| Product Cat#: | AB-06-1366 |
| Product type: | Primary antibody |
| Antigen: | DFNA5 |
| Immunogen: | KLH conjugated synthetic peptide derived from human DFNA5 21-120/496 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:450-1:2000) |
| Reactivity: | Human, Mouse, Rat, Dog, Cow, Sheep |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 0.01 M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | 2310037D07Rik |
| 4932441K13Rik | |
| Deafness, autosomal dominant 5 | |
| Deafness, autosomal dominant 5 protein | |
| DFNA5 | |
| DFNA5 gene | |
| DFNA5_HUMAN | |
| Dfna5h | |
| EG14210 | |
| Fin15 | |
| ICERE 1 | |
| ICERE-1 | |
| Inversely correlated with estrogen receptor expression 1 | |
| Non-syndromic hearing impairment protein 5 |
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Target information
Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53.2 Publications Gasdermin-E, N-terminal: Switches CASP3-mediated apoptosis induced by TNF or danger signals, such as chemotherapy drugs, to pyroptosis. Produced by the cleavage of GSDME by CASP3, perforates cell membrane and thereby induces pyroptosis. After cleavage, moves to the plasma membrane where it strongly binds to inner leaflet lipids, bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate. Mediates secondary necrosis downstream of the mitochondrial apoptotic pathway and CASP3 activation as well as in response to viral agents. Exhibits bactericidal activity.
Provider
Erpantech Laboratory
