Anti-Deltex antibody
Specifications
| Product Cat#: | AB-06-1356 |
| Product type: | Primary antibody |
| Antigen: | Deltex |
| Immunogen: | KLH conjugated synthetic peptide derived from human Deltex 351-450/620 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:400-1:2000); Immunohistochemistry-Paraffin (1:500-1:800) |
| Reactivity: | Human, Mouse, Rat, Pig, Cow, Sheep |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 0.01 M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Deltex homolog 1 (Drosophila) |
| Deltex protein 1 | |
| Deltex-1 | |
| Deltex1 | |
| Dtx1 | |
| E3 ubiquitin protein ligase DTX1 | |
| FXI-T1 | |
| Fxit 1 | |
| Fxit1 | |
| DTX1_HUMAN | |
| HDTX1 | |
| HDx 1 | |
| MDTX1 |
Target information
Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1.
Provider
Erpantech Laboratory
