Anti-DDX3X antibody
Specifications
| Product Cat#: | AB-06-1344 |
| Product type: | Primary antibody |
| Antigen: | DDX3X |
| Immunogen: | Purified recombinant fragment of human DDX3X expressed in E. Coli. |
| Species immunized: | Mouse |
| Isotype: | IgG2a |
| Applications: | Western Blot (1:500-1:2500); Immunohistochemistry (1:100-1:200); Flow Cytometry (1:50-1:200); Immunocytochemistry (1:100-1:200) |
| Reactivity: | Human, Mouse, Monkey, Rat |
| Clonality (clone number): | Monoclonal, E3-B9 |
| Form: | Liquid |
| Buffer: | 1*TBS (pH 7.4), 1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein G affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | ATP dependent RNA helicase DDX3X antibody |
| ATP-dependent RNA helicase DDX3X antibody | |
| CAP Rf antibody | |
| DBX antibody | |
| DDX14 antibody | |
| DDX3X antibody | |
| DDX3X_HUMAN antibody | |
| DEAD (Asp Glu Ala Asp) box polypeptide 3 X linked antibody | |
| DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked antibody | |
| DEAD box antibody | |
| DEAD box protein 3 antibody | |
| DEAD box protein 3 X-chromosomal antibody | |
| DEAD box X isoform antibody | |
| DEAD box, X isoform antibody | |
| DEAD/H (Asp Glu Ala Asp/His) box polypeptide 3 antibody | |
| DEAD/H box 3 antibody | |
| DEAD/H box 3, X-linked antibody | |
| Helicase like protein 2 antibody | |
| Helicase-like protein 2 antibody | |
| HLP2 antibody | |
| X isoform antibody | |
| X-chromosomal antibody |
Target information
Multifunctional ATP-dependent RNA helicase. The ATPase activity can be stimulated by various ribo- and deoxynucleic acids indicative for a relaxed substrate specificity. In vitro can unwind partially double-stranded DNA with a preference for 5′-single-stranded DNA overhangs. Is involved in several steps of gene expression, such as transcription, mRNA maturation, mRNA export and translation. However, the exact mechanisms are not known and some functions may be specific for a subset of mRNAs. Involved in transcriptional regulation. Can enhance transcription from the CDKN1A/WAF1 promoter in a SP1-dependent manner. Found associated with the E-cadherin promoter and can down-regulate transcription from the promoter. Involved in regulation of translation initiation. Proposed to be involved in positive regulation of translation such as of cyclin E1/CCNE1 mRNA and specifically of mRNAs containing complex secondary structures in their 5’UTRs; these functions seem to require RNA helicase activity. Specifically promotes translation of a subset of viral and cellular mRNAs carrying a 5’proximal stem-loop structure in their 5’UTRs and cooperates with the eIF4F complex.
Provider
Erpantech Laboratory