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Anti-NRG1 Isoform-10 antibody

SKU Product Brand Unit Availability Price Quantity  
AB-07-3372
Anti-NRG1 Isoform-10 antibody
Erpan Tech In stock

Specifications        

Product Cat#: AB-07-3372
Product type: Primary antibody
Antigen: NRG1 isoform-10
Immunogen: A synthetic peptide derived from human NRG1 isoform-10. The exact amino-acid sequence is proprietary.
Species immunized: Rabbit
Isotype: IgG
Applications: ELISA (1:10000); Western Blot (1:500-1:2500); Immunohistochemistry (1:50-1:100)
Reactivity: Human, Mouse, Rat
Clonality (clone number): Polyclonal
Form: Liquid
Buffer: PBS (without Mg2+ and Ca2+ ), pH 7.4, 0.02% sodium azide and 50% glycerol
Concentration: 1 mg/ml
Purity: Antigen affinity chromatography
Storage: Aliquot and freeze at -20°C. Avoid multiple freeze/thaw cycles.
Alternative names: Pro-neuregulin-1, membrane-bound isoform; Pro-NRG1; NRG1; GGF, HGL, HRGA, NDF, SMDF
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Target information

Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Binds to ERBB4 (PubMed:10867024, PubMed:7902537). Binds to ERBB3 (PubMed:20682778). Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling. Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:20682778). Ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons (By similarity).

Provider

Erpantech Laboratory

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MSDS-AB-07-3372.pdf (32 downloads )