Anti-Myelodysplasia Syndrome 1 antibody
Specifications
| Product Cat#: | AB-07-0851 |
| Immunogen: | A synthetic peptide derived from human Myelodysplasia Syndrome 1. The exact amino-acid sequence is proprietary. |
| Antigen: | Myelodysplasia Syndrome 1 |
| Product type: | Primary antibody |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | ELISA (1:1000); Western Blot (1:500~1:3000) |
| Reactivity: | Human |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Concentration: | 1 mg/ml |
| Purity: | Antigen affinity chromatography |
| Storage: | Aliquot and freeze at -20°C. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Myelodysplasia syndrome-associated protein 1; Myelodysplasia syndrome 1 protein |
Target information
Isoform 1:
Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis.6 Publications
Isoform 7:
Displays histone methyltransferase activity and monomethylates ‘Lys-9’ of histone H3 (H3K9me1) in vitro. Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 ‘Lys-9’ trimethylation. Likely to be one of the primary histone methyltransferases along with PRDM16 that direct cytoplasmic H3K9me1 methylation.
Provider
Erpantech Laboratory
