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Anti-SESN1 antibody

SKU Product Brand Unit Availability Price Quantity  
AB-07-2103
Anti-SESN1 antibody
Erpan Tech In stock

Specifications        

Product Cat#: AB-07-2103
Product type: Primary antibody
Antigen: SESN1
Immunogen: The antiserum was produced against synthesized peptide derived from internal of human SESN1.The exact amino-acid sequence is proprietary.
Species immunized: Rabbit
Isotype: IgG
Applications: Western Blot (1:500-1:2500); Immunohistochemistry (1:50-1:100); ELISA (1:15000);
Reactivity: Human; Mouse
Clonality (clone number): Polyclonal
Form: Liquid
Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02% sodium
azide and 50% glycerol.
Concentration: 1 mg/ml
Purity: Antigen affinity chromatography
Storage: Aliquot and freeze at -20°C. Avoid multiple freeze/thaw cycles.
Alternative names: Sestrin-1; P53-regulated protein PA26; SESN1
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Target information

Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed:25263562, PubMed:26449471). This stress-inducible metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity). May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1 (PubMed:23274085). May have an alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (By similarity). Was originally reported to contribute to oxidative stress resistance by reducing PRDX1 (PubMed:15105503). However, this could not be confirmed (By similarity).

Provider

Erpantech Laboratory

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MSDS-AB-07-2103.pdf (132 downloads )