Anti-GABA(B) R2 antibody
Specifications
| Product Cat#: | AB-06-1815 |
| Product type: | Primary antibody |
| Antigen: | GABA(B) R2 |
| Immunogen: | Amino acids 183-482 mapping within an extracellular domain of GABA(B) R2 of human origin. |
| Species immunized: | Mouse |
| Isotype: | IgG1 |
| Applications: | Western Blot (1:500-1:2000); Immunoprecipitation(1:50-1:500); Immunofluorescence(1-2 μg per 100-500 μg of total protein(1 ml of cell lysate) ) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Monoclonal (3G3) |
| Form: | Liquid |
| Buffer: | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| Alternative names: | BcDNA:GH07312 antibody |
| CG6706 antibody | |
| CT20836 antibody | |
| D Gaba2 antibody | |
| FLJ36928 antibody | |
| G protein coupled receptor 51 antibody | |
| G-protein coupled receptor 51 antibody | |
| GAB B R2 antibody | |
| GABA B R2 antibody | |
| GABA B receptor 2 antibody | |
| GABA-B receptor 2 antibody | |
| GABA-B-R2 antibody | |
| GABA-BR2 antibody | |
| GABAB R2 antibody | |
| GABABR 2 antibody | |
| GABABR2 antibody | |
| GABB R2 antibody | |
| GABBR 2 antibody | |
| Gabbr2 antibody | |
| GABR2_HUMAN antibody | |
| Gamma aminobutyric acid B receptor 2 antibody | |
| Gamma aminobutyric acid GABA B receptor 2 antibody | |
| Gamma aminobutyric acid type B receptor subunit 2 antibody | |
| Gamma-aminobutyric acid type B receptor subunit 2 antibody | |
| Gb 2 antibody | |
| Gb2 antibody | |
| GH07312 antibody | |
| GPR 51 antibody | |
| GPR51 antibody | |
| GPRC 3B antibody | |
| GPRC3B antibody | |
| HG 20 antibody | |
| HG20 antibody | |
| HRIHFB2099 antibody | |
| Metabotropic GABA B receptor subtype 2 antibody | |
| OTTHUMP00000021776 antibody | |
| OTTHUMP00000063797 antibody | |
| R2 SUBUNIT antibody |
Target information
Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:9872316, PubMed:9872744, PubMed:15617512, PubMed:18165688, PubMed:22660477, PubMed:24305054). Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (PubMed:18165688). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed:10075644, PubMed:10773016, PubMed:24305054). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (PubMed:10075644, PubMed:9872744, PubMed:10906333, PubMed:10773016). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (PubMed:9872744, PubMed:22660477). Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (PubMed:9872316, PubMed:10075644, PubMed:9872744, PubMed:22660477). Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (Probable).
Provider
Erpantech Laboratory