Anti-MRGX1 antibody
Specifications
| Product Cat#: | AB-07-0812 |
| Immunogen: | A synthetic peptide derived from human MRGX1. The exact amino-acid sequence is proprietary. |
| Antigen: | MRGX1 |
| Product type: | Primary antibody |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | ELISA (1:1000); Western Blot (1:500~1:3000); Immunofluorescence (1:100~1:500) |
| Reactivity: | Human |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Concentration: | 1 mg/ml |
| Purity: | Antigen affinity chromatography |
| Storage: | Aliquot and freeze at -20°C. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Mas-related G-protein coupled receptor member X1; Sensory neuron-specific G-protein coupled receptor 3/4; MRGPRX1; MRGX1, SNSR3, SNSR4 |
Show More
Target information
Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22)(PubMed:26582731). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. Activated by the antimalarial drug, chloroquine. May mediate chloroquine-induced itch, in a histamine-independent manner.
Provider
Erpantech Laboratory
