Anti-NMDAR1 (Ab-890) antibody
Specifications
| Product Cat#: | AB-07-3347 |
| Product type: | Primary antibody |
| Antigen: | NMDAR1 (Ab-890) |
| Immunogen: | A synthetic peptide derived from human NMDAR1 around the phosphorylation site of serine 890 (A-S-S/P-F-K). The exact amino-acid sequence is proprietary. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | ELISA (1:4500); Western Blot (1:500-1:2500); Immunohistochemistry (1:50-1:100); Immunofluorescence (1:100-1:500) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | PBS (without Mg2+ and Ca2+ ), pH 7.4, 0.02% sodium azide and 50% glycerol |
| Concentration: | 1 mg/ml |
| Purity: | Antigen affinity chromatography |
| Storage: | Aliquot and freeze at -20°C. Avoid multiple freeze/thaw cycles. |
| Alternative names: | GLURZ1, GRIN1, Glutamate [NMDA] receptor subunit zeta 1 precursor, N-methyl-D-aspartate receptor, NMD-R1, NMDZ1, NMZ1, NR1 |
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Target information
Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:7685113, PubMed:28126851, PubMed:26919761, PubMed:26875626, PubMed:28105280). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:26919761).
Provider
Erpantech Laboratory
