Anti-NOX4phox antibody
Specifications
| Product Cat#: | AB-06-3179 |
| Product type: | Primary antibody |
| Antigen: | NOX4 |
| Immunogen: | Recombinant protein |
| Species immunized: | Mouse |
| Isotype: | IgG1 |
| Applications: | Western Blot (1:500-1:2000); Immunocytochemistry (1:100-1:200); Immunohistochemistry(1:100-1:200); Flow Cytometry (1:10-1:200) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal(G11-H2) |
| Form: | Liquid |
| Buffer: | 1*TBS (pH7.4), 1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Kidney oxidase 1 antibody |
| Kidney oxidase-1 antibody | |
| Kidney superoxide producing NADPH oxidase antibody | |
| Kidney superoxide-producing NADPH oxidase antibody | |
| KOX 1 antibody | |
| KOX antibody | |
| Kox-1 antibody | |
| KOX1 antibody | |
| NADPH antibody | |
| NADPH oxidase 4 antibody | |
| Nox4 antibody | |
| NOX4_HUMAN antibody | |
| Renal NAD(P)H oxidase antibody | |
| Renal NAD(P)H-oxidase antibody | |
| RENOX antibody |
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Target information
Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 5 and isoform 6 display reduced activity.
Isoform 4: Involved in redox signaling in vascular cells. Constitutively and NADPH-dependently generates reactive oxygen species (ROS). Modulates the nuclear activation of ERK1/2 and the ELK1 transcription factor, and is capable of inducing nuclear DNA damage. Displays an increased activity relative to isoform 1.
Provider
Erpantech Laboratory
