Anti-RNF144B antibody
Specifications
| Product Cat#: | AB-07-2082 |
| Product type: | Primary antibody |
| Antigen: | RNF144B |
| Immunogen: | A synthetic peptide derived from N-terminal of human RNF144B. The exact amino-acid sequence is proprietary. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:2500); ELISA (1:35000) |
| Reactivity: | Human, Mouse |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | PBS (without Mg2+ and Ca2+ ), pH 7.4, 0.02% sodium azide and 50% glycerol |
| Concentration: | 1 mg/ml |
| Purity: | Antigen affinity chromatography |
| Storage: | Aliquot and freeze at -20°C. Avoid multiple freeze/thaw cycles. |
| Alternative names: | BA528A10.3; E3 ubiquitin-protein ligase RNF144B; IBR domain containing 2; IBR domain-containing protein 2; IBRDC2; KIAA0161; MGC71786; P53-inducible RING finger protein; P53RFP; R144B; ring finger 144B; RING finger protein 144B; RNF144B |
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Target information
E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se.
Provider
Erpantech Laboratory
