Anti-GRC5 antibody
Specifications
| Product Cat#: | AB-06-2034 |
| Product type: | Primary antibody |
| Antigen: | GRC5 |
| Immunogen: | KLH conjugated synthetic peptide derived from human GRC5/PHF2 1001-1096/1096 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:2000) |
| Reactivity: | Human, Mouse, Rat, Chicken, Horse, Sheep |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| Alternative names: | CENP-35 |
| GRC5 | |
| PHF2 | |
| JHDM1E | |
| Jumonji C domain containing histone demethylase 1E | |
| jumonji containing protein | |
| Lysine-specific demethylase PHF2 | |
| PHD finger protein 2 | |
| Phf2 |
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Target information
Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated ‘Lys-9’ of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated ‘Lys-4’ of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA.
Provider
Erpantech Laboratory
