Anti-Gremlin antibody
Specifications
| Product Cat#: | AB-06-2035 |
| Product type: | Primary antibody |
| Antigen: | Gremlin |
| Immunogen: | KLH conjugated synthetic peptide derived from human gremlin 101-184/184 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:2000) |
| Reactivity: | Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| Alternative names: | CKTSF1B1 |
| GREMLIN-1 | |
| GREMLIN 1 | |
| GREMLIN1 | |
| Cysteine knot superfamily BMP antagonist 1 | |
| DAND2 | |
| DRM | |
| GREMLIN | |
| Gremlin1 | |
| Gremlin 1 | |
| Gremlin-1 | |
| IHG2 | |
| PIG2 |
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Target information
Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner (By similarity). Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro) (PubMed:27036124). Acts as inhibitor of monocyte chemotaxis. Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed (By similarity).
Provider
Erpantech Laboratory
