Anti-GRK2 antibody
Specifications
| Product Cat#: | AB-06-2043 |
| Product type: | Primary antibody |
| Antigen: | GRK2 |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:1000-1:2000); Immunohistochemistry (1:50-1:200) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Monoclonal (ST05-60) |
| Form: | Liquid |
| Buffer: | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | ADRBK1 antibody |
| Adrenergic beta receptor kinase 1 antibody | |
| ARBK1_HUMAN antibody | |
| BARK antibody | |
| BARK1 antibody | |
| Beta adrenergic receptor kinase 1 antibody | |
| Beta ARK 1 antibody | |
| Beta ARK1 antibody | |
| Beta-adrenergic receptor kinase 1 antibody | |
| Beta-ARK-1 antibody | |
| FLJ16718 antibody | |
| G protein coupled receptor kinase 2 antibody | |
| G-protein coupled receptor kinase 2 antibody | |
| GRK2 antibody |
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Target information
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (PubMed:19306925, PubMed:19715378). Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by faciltating the trafficking of SMO into the cilium and the stimulation of SMO activity (By similarity).
Provider
Erpantech Laboratory