Anti-NEDD8 antibody
Specifications
| Product Cat#: | AB-07-3328 |
| Product type: | Primary antibody |
| Antigen: | NEDD8 |
| Immunogen: | A synthetic peptide derived from human NEDD8. The exact amino-acid sequence is proprietary. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | ELISA (1:4500); Western Blot (1:500-1:2500); Immunohistochemistry (1:50-1:100) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | PBS (without Mg2+ and Ca2+ ), pH 7.4, 0.02% sodium azide and 50% glycerol |
| Concentration: | 1 mg/ml |
| Purity: | Antigen affinity chromatography |
| Storage: | Aliquot and freeze at -20°C. Avoid multiple freeze/thaw cycles. |
| Alternative names: | NED8, NEDD-8, Ubiquitin-like protein NEDD8 |
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Target information
Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.
Provider
Erpantech Laboratory
