Anti-DC-SIGN antibody
Specifications
| Product Cat#: | AB-06-1329 |
| Product type: | Primary antibody |
| Antigen: | DC-SIGN |
| Immunogen: | KLH conjugated synthetic peptide derived from human DC-SIGN/CD209 51-150/1404 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:1000-1:2000); Flow Cytometry (1μg/Test); Immunohistochemistry-Paraffin (1:500-1:800) |
| Reactivity: | Human |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 0.01 M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | CLEC4L |
| Dendritic cell-specific ICAM-3-grabbing non-integrin 1 | |
| C type lectin domain family 4 member L | |
| CD 209 | |
| CD209 | |
| CD209 antigen | |
| CD209 antigen-like protein A | |
| CD209 molecule | |
| Cd209a | |
| CDSIGN | |
| CIRE | |
| DC SIGN1 | |
| DCSIGN | |
| Dendritic cell specific ICAM 3 grabbing nonintegrin 1 | |
| Dendritic cell specific ICAM3 grabbing nonintegrin 1 | |
| Dendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbing non-integrin | |
| Dengue fever, protection against, included | |
| Dentritic Cell Specific ICAM3 Grabbing Nonintegrin | |
| HIV GP120 Binding Protein | |
| MGC129965 | |
| MGC130443 | |
| SIGN-R1 |
Target information
Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response.On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells.
Provider
Erpantech Laboratory
