Anti-Phospho-Nrf2 (S40) antibody
Specifications
| Product Cat#: | AB-06-3522 |
| Product type: | Primary antibody |
| Antigen: | Phospho-Nrf2 (S40) |
| Immunogen: | Synthetic phospho-peptide corresponding to residues surrounding Ser345 of human MLKL. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Immunohistochemistry(1:40-1:100) |
| Reactivity: | Mouse |
| Clonality (clone number): | Monoclonal (SU0334) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA; 40% glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Erythroid derived 2 antibody |
| HEBP1 antibody | |
| Like 2 antibody | |
| NF E2 related factor 2 antibody | |
| NF-E2-related factor 2 antibody | |
| NF2L2_HUMAN antibody | |
| NFE2 related factor 2 antibody | |
| NFE2-related factor 2 antibody | |
| Nfe2l2 antibody | |
| Nrf 2 antibody | |
| NRF2 antibody | |
| Nuclear factor (erythroid derived 2) like 2 antibody | |
| Nuclear factor antibody | |
| Nuclear factor erythroid 2 like 2 antibody | |
| Nuclear factor erythroid 2 related factor 2 antibody | |
| Nuclear factor erythroid 2-related factor 2 antibody | |
| Nuclear factor erythroid derived 2 like 2 antibody |
Target information
The NF-E2 DNA binding protein is composed of two subunits, p45 and MafK. It regulates expression of globin genes in developing erythroid cells through interaction with Maf recognition elements (Mares). A family of NF-E2- related proteins, which are collectively known as the Cap ‘n’ collar (CNC) family and include Nrf1 (also designated TCF11), Nrf2 and Nrf3, are bZIP transcription factors that heterodimerize with Maf proteins to bind Mare sequences. The Nrf proteins also bind the antioxidant response element (ARE) and are implicated in the regulation of detoxification enzymes and the oxidative stress response. They do so by heterodimerizing with Jun family members (c-Jun, Jun B and Jun D) to activate gene expression, specifically the detoxifying enzyme NQO1. Nrf2 is widely expressed and is thought to translocate to the nucleus after treatment with xenobiotics and antioxidants, which stimulate its release from its repressor protein, Keap1. The gene encoding human Nrf3 maps to chromosome 7p15.2. Nrf3 is highly expressed in placenta, B cells and monocytes.
Provider
Erpantech Laboratory
