Anti-RPC5 antibody
Specifications
| Product Cat#: | AB-07-2089 |
| Product type: | Primary antibody |
| Antigen: | RPC5 |
| Immunogen: | A synthetic peptide derived from internal of human RPC5. The exact amino-acid sequence is proprietary. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Immunohistochemistry (1:50-1:100); Immunofluorescence(1:100-1:500); ELISA (1:35000) |
| Reactivity: | Human (Identities = 100%, Positives = 100%); Mouse (Identities = 92%, Positives = 100%) |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol |
| Concentration: | 1 mg/ml |
| Purity: | Antigen affinity chromatography |
| Storage: | Aliquot and freeze at -20°C. Avoid multiple freeze/thaw cycles. |
| Alternative names: | DNA-directed RNA polymerase III subunit RPC5,RNA polymerase III subunit C5; DNA-directed RNA polymerase III 80 kDa polypeptide |
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Target information
DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I (Pol I) and III (Pol III) which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPC40 is part of the polymerase core and may function as a clamp element that moves to open and close the cleft (PubMed:18160037, PubMed:24153182, PubMed:24153184). Plays an important role in targeting retrotransposons Ty integration upstream of pol III-transcribed genes such as tRNA genes, allowing Ty1, Ty2 and Ty4 to proliferate and yet minimizing genetic damage (PubMed:25931562).
Provider
Erpantech Laboratory
