Anti-PDX1 antibody
Specifications
| Product type: | Primary antibody | |
| Antigen: | PDX1 | |
| Immunogen: | Recombinant protein | |
| Species immunized: | Rabbit | |
| Isotype: | IgG | |
| Applications: | Western Blot (1:550); Immunofluorescence(1:100-1:250); Immunocytochemistry (1:100-1:250)/ Immunohistochemistry | |
| Reactivity: | Human | |
| Clonality (clone number): | Monoclonal | |
| Buffer: | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. | |
| Concentration: | 1mg/ml | |
| Purity: | Protein A affinity purified | |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. | |
| Alternative names: | Glucose sensitive factor antibody | |
| Glucose-sensitive factor antibody | ||
| GSF antibody | ||
| IDX 1 antibody | ||
| IDX-1 antibody | ||
| IDX1 antibody | ||
| Insulin promoter factor 1 antibody | ||
| Insulin promoter factor 1 homeodomain transcription factor antibody | ||
| Insulin upstream factor 1 antibody | ||
| IPF 1 antibody | ||
| IPF-1 antibody | ||
| IPF1 antibody | ||
| Islet/duodenum homeobox 1 antibody | ||
| Islet/duodenum homeobox-1 antibody | ||
| IUF 1 antibody | ||
| IUF-1 antibody | ||
| IUF1 antibody | ||
| MODY4 antibody | ||
| Pancreas/duodenum homeobox 1 antibody | ||
| Pancreas/duodenum homeobox protein 1 antibody | ||
| pancreatic and duodenal homeobox P antibody | ||
| PDX 1 antibody | ||
| PDX-1 antibody | ||
| PDX1 antibody | ||
| PDX1_HUMAN antibody | ||
| Somatostatin transactivating factor 1 antibody | ||
| Somatostatin-transactivating factor 1 antibody | ||
| STF 1 antibody | ||
| STF-1 antibody | ||
| STF1 antibody |
Target information
Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5′-[CT]TAAT[TG]-3′. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell.
Provider
Erpantech Laboratory